|
Researching and writing a literature review Biomedical Skills |
|
|
|
4.3 Evidence for and against
You need to show your marker that you have read broadly and looked at your topic from different angles. In research people often disagree or our current knowledge is incomplete. You need to weigh up the evidence from the different articles you’ve read and decide what you think about the topic.
Activity
Read the paragraph from a student's literature review and answer the questions below.
Protein Kinase C (PKC) Inhibitors Only one drug has been approved that targets protein kinase C (PKC): midostaurin. It has been demonstrated that by inhibiting with midostaurin, eNOS activity can be restored in animal models, namely increased vasodilation, reduced ROS production and reversed eNOS uncoupling (20). Midostaurin however was approved for cancer treatments and would not be a viable option as a long-term treatment for cardiovascular disease, because PKC is widespread throughout the body and plays numerous vital roles in intracellular signalling (30). Midostaurin has several adverse side effects and cannot be used for extended treatment without systemic toxicity (21, 30). PKC is unlikely to be a good target for long-term cardiovascular therapies unless greater specificity can be achieved. |
2. What is the evidence against targeting Protein Kinase C (PKC) to treat long-term cardiovascular disease? [Multiply answers are correct]
